Akihiko Hoshide was born in 1968 in Tokyo. He received a bachelor's degree in Mechanical Engineering from Keio University in 1992 and a master of science in Aerospace Engineering from the University of Houston, Cullen College of Engineering in 1997.
Hoshide joined the National Space Development Agency of Japan (NASDA, currently Japan Aerospace Exploration Agency) in 1992 and worked as a member of NASDA's Nagoya office for two years. At the Nagoya office, he was involved in the development of the H-II rocket. From 1994 to 1999, he worked as an astronaut support engineer for the NASDA Astronaut Office, supporting the development of the astronaut training program and the evaluation of crew interfaces designs. He also supported astronaut Koichi Wakata during his training and mission on the STS-72 mission.
In February 1999, Hoshide was selected by NASDA as one of three Japanese astronaut candidates for the International Space Station (ISS), together with Dr. Satoshi Furukawa and Naoko Yamazaki.
Hoshide started NASDA's Basic Training program in April 1999 and was certified as an astronaut in January 2001. He then participated in ISS Advanced Training, while working on development of the hardware and operation of the Japanese Experiment Module "Kibo" and the H-II Transfer Vehicle (HTV).
In May 2004, Hoshide was certified as a Soyuz-TMA Flight Engineer. He was dispatched to NASA's Johnson Space Center (JSC) in June 2004. He went through training (Astronaut Candidate Training) at JSC for about a year and eight months, and was qualified for flight assignments aboard the space shuttle as a Mission Specialist in Feb, 2006.
In March 2007, Hoshide was selected as a crew member for the STS-124 (1J) mission, the second of three Kibo assembly-related missions, which delivered the Japanese Experiment Module "Kibo" to the International Space Station (ISS).
In June 2008, he flew to the ISS on the STS-124 mission. He installed Kibo's Pressurized Module (PM) on the ISS using the Space Station Remote Manipulator System (SSRMS). He also operated the SSRMS for relocation of the Experiment Logistics Module-Pressurized Section (ELM-PS). During the mission, he performed Kibo-related activities, such as activations of the PM and Kibo's robotic arm, the JEM Remote Manipulator System (JEMRMS).
In November 2009, he was assigned as a flight engineer for the ISS Expedition 32/33 mission.
From July to November 2012, he stayed on the ISS for 124 days as a flight engineer for the Expedition 32/33 mission. His mission included experiments in Kibo, ISS maintenance, three times of Extravehicular Activity (EVA), and deployment of CubeSats using the JEM Small Satellite Orbital Deployer (J-SSOD). He also supported the arrivals and departures of various types of spacecraft including H-II Transfer Vehicle (HTV) KOUNOTORI3 and Dragon cargo spacecraft (SpX-1). He flew on the Soyuz TMA-05M spacecraft (31S) for both launch and return.
In July 2014, he served as Commander of the 18th NASA Extreme Environment Mission Operations (NEEMO18), an undersea expedition at the National Oceanic & Atmospheric Administration's "Aquarius" habitat.
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